Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RIP |
| Sample | cell lines (Huh7, Hep3B, HepG2, Bel-7404, SK-Hep1, LO2 and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | miR-485 was significantly downregulated in HCC cells.miR-485 was increased by sh-NEAT1 and miR-485 can modulate NEAT1 expression negatively. miR-485 was confirmed as a interacting target of NEAT1.STAT3 was recognized as a direct target of miR-485 and miR-485 mimics can inhibit STAT3 expression.NEAT1 can act as a competing endogenous lncRNA (ceRNA) to regulated STAT3 by sponging miR-485 in HCC. Taken these together, NEAT1 can be used as an important biomarker in HCC diagnosis and treatment.STAT3 can regulate various genes which can control proliferation, survival, and invasion process. |
| Pubmed ID | 29219178 |
| Year | 2017 |
| Title | The long noncoding RNA NEAT1 contributes to hepatocellular carcinoma development by sponging miR-485 and enhancing the expression of the STAT3. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |