Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Flow cytometry assay etc. |
| Sample | CRC tissues, cell lines (HCT116, LoVo, HT29 and SW480) |
| Expression Pattern | up-regulated |
| Function Description | Results showed that NEAT1 was significantly overexpressed in CRC cells and tissues. Clinicpathologic detection verified that high NEAT1 expression associated with bulk in CRC. The serum contents of NEAT1 were observably elevated comparing with healthy cases. The levels of NEAT1 were elevated in distinguishing CRC from normal. Further experiments illustrated that of NEAT1 knockdown signally inhibited growth and facilitated apoptosis. |
| Pubmed ID | 28013491 |
| Year | 2016 |
| Title | LncRNA NEAT1 Impacts Cell Proliferation and Apoptosis of Colorectal Cancer via Regulation of Akt Signaling. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |