Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (SCC-9,SCC-25, HN4, Tca-8113,Cal-27), OSCC tissues |
| Expression Pattern | up-regulated |
| Function Description | Functionally,knockdown of NEAT1 significantly inhibited cell proliferation and invasion and induced cell cycle arrest at the G0/G1 phase and apoptosis, whereas inhibition of miR-365 abolished the suppressive effect of NEAT1 knockdown on cellular processes. RGS20, a direct target of miR-365, could reverse the tumor suppressive role of miR-365 mimic by enhancing cell viability and motility. Moreover, the protein levels of RGS20, cyclin D1, E-cadherin, N-cadherin and vimentin could be regulated by the NEAT1/miR-365 axis.NEAT1 silencing also inhibited tumor growth in vivo. NEAT1/miR-365/RGS20 axis may be a novel mechanism or therapeutic strategy for OSCC treatment. |
| Pubmed ID | 29484420 |
| Year | 2018 |
| Title | lncRNA NEAT1 promotes cell proliferation and invasion by regulating miR-365/RGS20 in oral squamous cell carcinoma. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |