Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | cell lines (BGC823, SGC-7901, AGS, MGC803, MKN28), cell lines (GES-1 and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 and STAT3 expression were significantly upregulated in human gastric cancer cells including BGC823, SGC-7901,AGS, MGC803 and MKN28 cells compared to normal gastric epithelial cells GES-1 while miR-506 was downregulated.the negative binding correlation between NEAT1 and miR-506. In addition, miR-506 can modulate expression of NEAT1 in vitro. STAT3 was predicted as an mRNA target of miR-506 and miR-506 mimics can suppress STAT3 mRNA expression.downregulation of NEAT1 can restrain gastric cancer development by decreasing STAT3 which can be reversed by miR-506 inhibitors. |
| Pubmed ID | 29363783 |
| Year | 2018 |
| Title | Long noncoding RNA NEAT1-modualted miR-506 regulates gastric cancer development through targeting STAT3. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |