Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute promyelocytic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (NB4 and 293T) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we performed chromatin immunoprecipitation and luciferase reporter assays to demonstrate that C/EBP family transcription factor C/EBPB bind to and transactivate the promoter of lncRNA NEAT1 through the C/EBPB binding sites both around -54 bp and -1453 bp upstream of the transcription start site. Moreover, the expression of C/EBPB was increased after ATRA treatment, and the binding of C/EBPB in the NEAT1 promoter was also dramatically increased. Finally, knockdown of C/EBPB significantly reduced the ATRA-induced upregulation of NEAT1. In conclusion, C/EBPB directly activates the expression of NEAT1 through binding to the promoter of NEAT1. Knockdown of C/EBPB impairs ATRA-induced transcriptional activation of NEAT1. |
| Pubmed ID | 29111326 |
| Year | 2018 |
| Title | C/EBPB contributes to transcriptional activation of long non-coding RNA NEAT1 during APL cell differentiation. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for acute promyelocytic leukemia | OMIM COSMIC |