Basic Information
| LncRNA/CircRNA Name | BC032913 |
| Synonyms | DPP10-AS1, BC032913 |
| Region | GRCh38_2:115130935-115161343 |
| Ensemble | ENSG00000235026 |
| Refseq | NR_036580 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay |
| Sample | Human colorectal cancer cell lines (HCT116 , DLD-1) |
| Expression Pattern | up-regulated |
| Function Description | Our findings indicate that the novel lncRNA BC032913 could serve as a novel prognostic marker and effective therapeutic target for CRC. A total of 115 CRC patients were included in the survival analysis, which was conducted using the Kaplan-Meier method. A log-rank test was employed to compare differences between survival curves. Although TIMP3 plays a significant role in cancers, limited data are available regarding the mechanism of TIMP3 dysregulation. It has been documented that aberrant methylation of TIMP-3 occurs in primary cancers of the colon, lung, breast, kidney, and brain. |
| Pubmed ID | 28918047 |
| Year | 2017 |
| Title | Long Noncoding RNA BC032913 as a Novel Therapeutic Target for Colorectal Cancer that Suppresses Metastasis by Upregulating TIMP3 |
External Links
| Links for BC032913 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |