Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, RNAi, Western blot, RNA pull-down assay, Cell migration and invasion assay etc. |
| Sample | cell lines (CBMs, TAMs, BMDMs, RAW 264.7) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 was highly expressed in patients with thyroid cancer. NEAT1 knockout inhibited thyroid cancer cell survival, migration and invasion, along with reduced B-catenin (a direct target of miRNA-214) protein expression. Furthermore, NEAT1 significantly accelerated thyroid cancer cell growth and metastasis in vitro and increased tumor size in vivo. Upregulation of NEAT1 decreased the expression of miRNA-214, presenting a reciprocal repression correlation. |
| Pubmed ID | 28000845 |
| Year | 2016 |
| Title | Long non-coding RNA NEAT1 promotes malignant progression of thyroid carcinoma by regulating miRNA-214. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |