Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | melanoma cancer tissues, melanoma cell lines of M14, 451LU, A875, A375, and A2058, epidermal melanocytes neonatal cells (HEMn) |
| Expression Pattern | up-regulated |
| Function Description | the expression of NEAT1 was signifcantly upregulated in melanoma tissues, which remarkedly promoted the cells proliferation, cell migration, and invasion in melanoma cell lines. Besides, NEAT1 could directly bind to miR-23a-3p, which was found to reverse the efect caused by NEAT1. MiR-23a-3p was discovered to bind to 3 UTR of KLF3, which reduced KLF3 expression. In addition, the overexpression of KLF3 could lower the efects of miR-23a-3p caused on melanoma cancer cell development. Conclusion: Our results demonstrated that NEAT1 could sponge miR-23a-3p and functions via the expression of KLF3. This axis of NEAT1/miR-23a-5p/KLF3 could together regulate melanoma cancer proliferation. |
| Pubmed ID | 31462890 |
| Year | 2019 |
| Title | NEAT1/miR-23a-3p/KLF3: a novel regulatory axis in melanoma cancer progression |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |