Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | OS tissues, Human OS cell lines (HOS, SaOS2, MG63, and U2OS) and a human osteoblastic cell line (hFOB1.19) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 expression was significantly upregulated in OS tissues and cell lines. High NEAT1 expression was closely associated with advanced clinicopathologic features and poor overall survival of patients with OS. Using in vitro function assay, we found that NEAT1 could promote the proliferation, invasion, and epithelial mesenchymal transition (EMT) process of OS cells. NEAT1 could also promote OS cell growth in vivo. In addition, our studies showed that miR 186 5p was a downstream target of NEAT1 in OS. Functionally, miR 186 5p suppressed the proliferation, invasion, and EMT process of OS cells. Furthermore, our data revealed that HIF 1? was a downstream target of miR 186 5p and that NEAT1 could exert its tumor oncogenic roles on OS cells via the miR 186 5p/HIF 1? axis. |
| Pubmed ID | 30485482 |
| Year | 2018 |
| Title | lncRNA nuclear-enriched abundant transcript 1 promotes cell proliferation and invasion by targeting miR-186-5p/HIF-1? in osteosarcoma |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |