Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | glioma tissues, Glioma cell lines U251, SHG-44, TJ905 and human astrocyte cell line HA,HEK-293T cells |
| Expression Pattern | up-regulated |
| Function Description | LncRNA NEAT1 and CDK6 were highly expressed in glioma tissues and cells, whereas miR 139 5p was lowly expressed. There were target relationships and correlations on expressions between miR 139 5p and NEAT1/ CDK6. NEAT1 and CDK6 could promote cell proliferation and metastasis of glioma cells and impeded cell apoptosis, whereas miR 139 5p exerted suppressive effects on the biological functions of glioma cells. NEAT1 regulated CDK6 to affect glioma growth through sponging miR 139 5p |
| Pubmed ID | 30515782 |
| Year | 2018 |
| Title | Long noncoding RNA nuclear enriched abundant transcript 1 impacts cell proliferation, invasion, and migration of glioma through regulating miR-139-5p/CDK6 |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |