Basic Information
| LncRNA/CircRNA Name | BC032469 |
| Synonyms | CTD-3080P12.3 |
| Region | GRCh38_5:1173141-1178605 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues, cell lines (KATO-III, SGC-7901, MKN28, AGS, MKN45) |
| Expression Pattern | up-regulated |
| Function Description | Here, we report that BC032469, a novel lncRNA, expressed highly in gastric cancer tissues, and the upregulation was clinically associated with larger tumor size, poor differentiation and shorter survival of gastric cancer patients. Mechanistically, BC032469 could directly bind to miR-1207-5p and effectively functioned as a sponge for miR-1207-5p to modulate the derepression of hTERT. Thus, BC032469 may function as a ceRNA to impair miR-1207-5p-dependent hTERT downregulation, suggesting that it may be clinically valuable as a poor prognostic biomarker of gastric cancer. |
| Pubmed ID | 26549025 |
| Year | 2015 |
| Title | Long noncoding RNA BC032469, a novel competing endogenous RNA, upregulates hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer. |
External Links
| Links for BC032469 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |