Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | CRC tissues and cell lines (SW620, SW480, HCT116, HT29, CaCo-2, LoVo and Colo205) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we report that NEAT1 expression is up-regulated in colorectal cancer tissues, which correlates with advanced clinical features, poor overall survival and disease free survival. Up-regulated NEAT1 promotes cell proliferation and metastasis of colorectal cancer both in vitro and in vivo. Moreover, NEAT1 functions as an oncogene influencing cell viability and invasion in part by serving as a competing endogenous RNA (ceRNAs) modulating miRNA-34a expression, leading to subsequent repression of the miR-34a/SIRT1 axis and activation of the Wnt/?-catenin signaling pathway. |
| Pubmed ID | 30312725 |
| Year | 2019 |
| Title | Long Non-Coding RNA NEAT1 Promotes Colorectal Cancer Progression by Competitively Binding miR-34a With SIRT1 and Enhancing the Wnt/?-catenin Signaling Pathway |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |