Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | CRC Cell lines HCT116 and HT29 |
| Expression Pattern | up-regulated |
| Function Description | Here, we firstly revealed that repression of lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) inhibited cell proliferation and migration in HCT116 cells and overexpression of NEAT1 promoted cell proliferation and migration in SW480 cells using CCK8 assay and transwell assay. Then, we found that suppression of NEAT1 increased the miR-196a-5p expression in HCT116 cells, while elevation of NEAT1 decreased the miR-196a-5p expression in SW480 cells using qPCR assay. Furthermore, miR-196a-5p could bind to the predicted binding site of NEAT1. We then found that miR-196a-5p was involved in the role of NEAT1 in CRCs. |
| Pubmed ID | 30383193 |
| Year | 2018 |
| Title | LncRNA NEAT1 promotes colorectal cancer cell proliferation and migration via regulating glial cell-derived neurotrophic factor by sponging miR-196a-5p. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |