Basic Information
| LncRNA/CircRNA Name | BC032020 |
| Synonyms | NA |
| Region | GRCh38_6:57114894-57174236 |
| Ensemble | ENSG00000226803 |
| Refseq | NR_110742 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell lines (AsPC-1(CRL-1682), BxPC-3 (CRL-1687), PANC-1 (CRL-1469),CFPAC-1 (CRL-1918), MIA PaCa-2 (CRL-1420)), pancreatic cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | BC032020 levels in the PDAC tumor tissues were lower than those in the adjacent normal tissues, and ZNF451 expression inversely correlated with the BC032020 levels in the PDAC tumor tissues and cell lines. BC032020 overexpression led to a decrease in ZNF451 expression; it also suppressed the proliferation and migration of the AsPC-1 and PANC-1 cells, and induced G1 phase arrest and cell apoptosis. The results of in vivo experiments revealed that BC032020 suppressed tumor growth in a xenograft model by inhibiting ZNF451 expression. Taken together, the findings of this study indicate that BC032020 suppresses the survival of PDAC cells by inhibiting ZNF451 expression. |
| Pubmed ID | 29532883 |
| Year | 2018 |
| Title | LncRNA BC032020 suppresses the survival of human pancreatic ductal adenocarcinoma cells by targeting ZNF451. |
External Links
| Links for BC032020 | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |