Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot |
| Sample | cervical cancer tissues, cell line HeLa |
| Expression Pattern | up-regulated |
| Function Description | lncRNA NEAT1 expression was significantly increased in cervical cancer. LncRNA NEAT1 siRNA transfection can inhibit the proliferation of cervical cancer by regulating the AKT/PI3K signaling pathway, promote cell apoptosis, and restrain cell invasion. |
| Pubmed ID | 30024596 |
| Year | 2018 |
| Title | LncRNA NEAT1 Regulates Cervical Carcinoma Proliferation and Invasion by Targeting AKT/PI3K. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |