Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot, Dual luciferase reported assay |
| Sample | glioma tissues, cell lines (U87, U251, SHG-44, U-118MG, HEK-293) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 was up-regulated in glioma. Knockdown of NEAT1 inhibited glioma cells' viability, migration and invasion. MiR-132 was down-regulated while SOX2 was up-regulated in glioma cells. It can be concluded that NEAT1 knockdown is effective in restraining glioma cell growth and invasiveness. |
| Pubmed ID | 30053878 |
| Year | 2018 |
| Title | Knockdown of Long Non-Coding RNA NEAT1 Inhibits Glioma Cell Migration and Invasion via Modulation of SOX2 Targeted by miR-132. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |