Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Chronic myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase assay, ChIP |
| Sample | cell lines (K562, NB4, Molt4, HL60, Jurkat ) |
| Expression Pattern | up-regulated |
| Function Description | we found that nuclear-enriched abundant transcript 1 (NEAT1), a lncRNA essential for the formation of nuclear body paraspeckles, is significantly repressed in primary CML cells.Knockdown of NEAT1 could promote imatinib (IM)-induced apoptosis. |
| Pubmed ID | 30153828 |
| Year | 2018 |
| Title | The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for Chronic myeloid leukemia | OMIM COSMIC |