Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay |
| Sample | ovarian cancer tissues, cell lines (A2780, HO8910, SKOV3, OVCAR3, CAOV3, ES-2, OV420) |
| Expression Pattern | up-regulated |
| Function Description | Our results showed that elevated NEAT1 expression in human HGSOC specimens correlated with a poor prognosis. knockdown of NEAT1 significantly prohibited ovarian cancer cell proliferation and invasion in vitro and restrained tumor growth in vivo. NEAT1 functioned as a competing endogenous RNA (ceRNA) for miR-506 to promote cell proliferation and migration. |
| Pubmed ID | 30154460 |
| Year | 2018 |
| Title | Long noncoding RNA NEAT1, regulated by LIN28B, promotes cell proliferation and migration through sponging miR-506 in high-grade serous ovarian cancer. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |