Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | nuclear paraspeckle assembly transcript 1 |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | 5-fluorouracil | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Western blotting, qRT-PCR, Dual Luciferase assay |
| Sample | colonic epithelial cell line, FHC, and colorectal carcinoma cell lines, HT29, HCT8, HCT116, SW480, SW620,Colorectal tissue |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 expression was increased in CRC tissues and cells, which showed a negative correlation with miR-34a expression. In addition, NEAT1 knockdown noticeably inhibited the proliferation of CRC cells and enhanced 5-FU sensitivity. It revealed that NEAT1 knockdown suppressed the LC3 puncta and the expressions of Beclin-1, ULK1, and ratio of LC3II/I. Overexpression of miR-34a showed similar trends with NEAT1 knockdown. |
| Pubmed ID | 31802650 |
| Year | 2020 |
| Title | LncRNA NEAT1 Knockdown Attenuates Autophagy to Elevate 5-FU Sensitivity in Colorectal Cancer via Targeting miR-34a |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |