Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | nuclear paraspeckle assembly transcript 1 |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | RNA-seq, Western blot assay, RT-PCR |
| Sample | BC T24, 253J, Biu-87 cells |
| Expression Pattern | up-regulated |
| Function Description | the RNA level of NEAT1.1, one RNA variant of NEAT1, was reduced in cisplatin-sensitive T24 cells compared to cisplatin-resistant T24 (T24R) cells after both treated with cisplatin modulated through Wnt/?-catenin signaling pathway using RNA-seq. Furthermore, NEAT1.1 was knocked down within T24R cells and caused a phenotype of the compromised cell growth, invasion and enhanced apoptosis upon cisplatin treatment compared to untreated T24R cells. |
| Pubmed ID | 31933859 |
| Year | 2019 |
| Title | Silencing Long Non-Coding RNA NEAT1 Enhances the Suppression of Cell Growth, Invasion, and Apoptosis of Bladder Cancer Cells Under Cisplatin Chemotherapy |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |