Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | bone marrow tissues (AML samples and normal volunteers),cell lines (HL-60 and THP-1) |
| Expression Pattern | down-regulated |
| Function Description | NEAT1 and miR-194-5p were both down-regulated in AML. Overexpression of either NEAT1 or miR-194-5p repressed proliferation, induced apoptosis and restrained migration and invasion of AML cells. There was a negative correlation between NEAT1 and DNMT3A in AML. Knockdown of DNMT3A dramatically decreased the methylation of NEAT1. |
| Pubmed ID | 32179410 |
| Year | 2020 |
| Title | Down-regulation of lncRNA NEAT1 Regulated by miR-194-5p/DNMT3A Facilitates Acute Myeloid Leukemia |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |