Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | anaplastic thyroid cancer |
| ICD-0-3 | C73 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc |
| Sample | malignant tissues and adjacent non-malignant tissues, cell lines (SW1736 and KAT-18) |
| Expression Pattern | up-regulated |
| Function Description | In conclusion, our study suggested that a low NEAT1 expression suppressed the migration, invasion, and glycolysis in ATC cells under hypoxia at least partially through modulating miR-206 and miR-599, providing new therapeutic strategies for ATC treatment. |
| Pubmed ID | 32336952 |
| Year | 2020 |
| Title | Knockdown of lncRNA NEAT1 suppresses hypoxia-induced migration, invasion and glycolysis in anaplastic thyroid carcinoma cells through regulation of miR-206 and miR-599 |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for anaplastic thyroid cancer | OMIM COSMIC |