Basic Information
| LncRNA/CircRNA Name | NDRG1-OT1 |
| Synonyms | lnc-NDRG1-1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, etc. |
| Sample | MCF-7 breast cancer cells and HEK293T human embryonickidney cells |
| Expression Pattern | up-regulated |
| Function Description | LncRNA NDRG1-OT1 was found to be significantly upregulated in hypoxia and inhibited the expression of NDRG1 in several breast cancer cell lines; The first quarter fragment (1 149 nt) of NDRG1-OT 1 had no effect on the NDRG1 promoter; the second quarter fragment (150 263 nt) repressed NDRG1 by increasing the binding affinity of HNRNPA1; the third quarter fragment (264 392 nt) improved NDRG1 promoter activity by recruiting HIF-1?; the fourth quarter fragment (393 508 nt) down-regulated NDRG1 promoter activity via down-regulation of KHSRP under hypoxia. In summary, we have found a novel mechanism by which different fragments of the same lncRNA can cause opposite effects within the same target gene. |
| Pubmed ID | 30497328 |
| Year | 2018 |
| Title | Different effects of long noncoding RNA NDRG1-OT1 fragments on NDRG1 transcription in breast cancer cells under hypoxia |
External Links
| Links for NDRG1-OT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |