Basic Information
| LncRNA/CircRNA Name | ncRAN |
| Synonyms | SNHG16, Nbla10727, Nbla12061, ncRAN |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi etc. |
| Sample | CRC tissues, cell lines (LoVo, Caco-2, DLD1, SW620, SW480, HCT8, HCT116 etc.) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we demonstrated that ncRAN expression is significantly down-regulated in tumor tissue and CRC cell lines compared with adjacent normal tissue and a normal intestinal mucous cell line. Reduced expression of ncRAN was detected in poorly differentiated or undifferentiated tumors and in tumors with liver metastases. Kaplan-Meier analysis indicated that patients with lower ncRAN expression have a worse overall survival. |
| Pubmed ID | 24519959 |
| Year | 2014 |
| Title | Down-regulation of ncRAN, a long non-coding RNA, contributes to colorectal cancer cell migration and invasion and predicts poor overall survival for colorectal cancer patients. |
External Links
| Links for ncRAN | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |