Basic Information
| LncRNA/CircRNA Name | ncNRFR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Northern blot, in vitro knockdown etc. |
| Sample | colonic epithelial cell tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | Stable overexpression of ncNRFR in non-transformed, conditionally immortalized mouse colonocytes results in malignant transformation, as determined by growth in soft agar and formation of highly invasive tumors in nude mice. Moreover, ncNRFR appears to inhibit the function of the tumor suppressor let-7. These results suggest precise regulation of ncNRFR is necessary for proper cell growth in the colonic crypt, and its misregulation results in neoplastic transformation. |
| Pubmed ID | 24045012 |
| Year | 2013 |
| Title | Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA. |
External Links
| Links for ncNRFR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |