Basic Information
| LncRNA/CircRNA Name | NCK1-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi, RIP, other |
| Sample | Cervical cancer tissues and cell line (HeLa) |
| Expression Pattern | up-regulated |
| Function Description | Increased expression of NCK1-AS1, MSH2, and decreased expression of miR-134-5p were observed in cervical cancer tissues. In addition, NCK1-AS1 competitively bound to miR-134-5p to regulate MSH2. Therefore, si-NCK1-AS1 and miR-134-5p mimic both reduced MSH2 activity and increased cisplatin-induced apoptosis in cervical cancer cells. Taken together, NCK1-AS1 may become a novel target in improving the chemotherapeutic response and survival of cervical cancer patients. |
| Pubmed ID | 30221354 |
| Year | 2019 |
| Title | Suppression of Long Noncoding RNA NCK1-AS1 Increases Chemosensitivity to Cisplatin in Cervical Cancer |
External Links
| Links for NCK1-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |