Basic Information
| LncRNA/CircRNA Name | BC017993 |
| Synonyms | SNHG8, LINC00060, NCRNA00060 |
| Region | GRCh38_4:118278709-118279823 |
| Ensemble | ENSG00000269893 |
| Refseq | NR_003584 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | cell line (SH-SY5Y) |
| Expression Pattern | differential expression |
| Function Description | We found that intronic and bidirectional promoter architectures are associated with rapid RA-dependent induction or repression of the corresponding lncRNAs, followed by their constant expression. At the same time, lncRNAs expressed downstream of protein-coding genes are characterized by rapid induction, followed by transcriptional repression. Quantitative RT-PCR analysis confirmed the discovered functional modes for several selected lncRNAs associated with proteins involved in cancer and embryonic development. |
| Pubmed ID | 24555823 |
| Year | 2013 |
| Title | Role of genomic architecture in the expression dynamics of long noncoding RNAs during differentiation of human neuroblastoma cells. |
External Links
| Links for BC017993 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |