Basic Information
| LncRNA/CircRNA Name | NCK1-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | urinary bladder cancer |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | UBC tissues,cell lines(HT-1376 and HT-1197) |
| Expression Pattern | up-regulated |
| Function Description | It was observed that NCK1-AS1 was up-regulated, while miR-143 was down-regulated in tumor tissues than in adjacent healthy tissues of urinary bladder cancer (UBC) patients. A 5-year survival analysis showed that the survival rate of patients with high NCK1-AS1 level or low miR-143 level in tumor tissues appears relatively low. Correlation analysis revealed a significant inverse correlation between NCK1-AS1 and miR-143 in tumor tissues. |
| Pubmed ID | 32184669 |
| Year | 2020 |
| Title | LncRNA NCK1-AS1 Promotes Cancer Cell Proliferation and Increase Cell Stemness in Urinary Bladder Cancer Patients by Downregulating miR-143 |
External Links
| Links for NCK1-AS1 | GenBank HGNC NONCODE |
| Links for urinary bladder cancer | OMIM COSMIC |