Basic Information
| LncRNA/CircRNA Name | NBR2 |
| Synonyms | NA |
| Region | GRCh38_17:43125610-43153671 |
| Ensemble | ENSG00000198496 |
| Refseq | NR_003108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Luciferase reporter assay etc. |
| Sample | colorectal cancer tissues than in adjacent healthy tissues ,human colorectal carcinoma cell lines (RKO and HT115) |
| Expression Pattern | down-regulated |
| Function Description | NBR2 was downregulated in colorectal cancer tissues than in adjacent healthy tissues. Decreased expression levels of NBR2 in tumor tissues were observed with the increase of clinical stages. MiRNA-21 was upregulated in colorectal cancer tissues than in adjacent healthy tissues, and was significantly and inversely correlated with NBR2.NBR2 overexpression downregulated miRNA-21 in colorectal cancer cells, while miRNA-21 overexpression failed to significantly affect NBR2 expression. NBR2 overexpression suppressed migration and invasion of colorectal cancer cells.NBR2 inhibited colorectal cancer cell migration and invasion possibly by downregulating miRNA-21. |
| Pubmed ID | 31571148 |
| Year | 2019 |
| Title | LncRNA NBR2 Suppresses Migration and Invasion of Colorectal Cancer Cells by Downregulating miRNA-21 |
External Links
| Links for NBR2 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |