Basic Information
| LncRNA/CircRNA Name | NBR2 |
| Synonyms | NA |
| Region | GRCh38_17:43125610-43153671 |
| Ensemble | ENSG00000198496 |
| Refseq | NR_003108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | NSCLC tissues and paracancerous tissues ,human normal lung cell line (BEAS2B) and lung cancer cell lines(A549, AsPC-1, and H460) |
| Expression Pattern | down-regulated |
| Function Description | The expression of lncRNA NBR2 was decreased in NSCLC patients tissues, and the NSCLC patients in the NBR2 low expression group showed a poor prognosis. Meanwhile, the expression of NBR2 in patients with NSCLC was correlated with tumor size. Overexpression of NBR2 suppressed the viability and migration of NSCLC cells and the expression of Notch1 and EMT-related genes in AsPC-1 cells. Simultaneous overexpression of NBR2 and Notch1 could reverse the inhibitory effect of NBR2 on proliferation and migration of NSCLC cells. |
| Pubmed ID | 31599420 |
| Year | 2019 |
| Title | LncRNA NBR2 Inhibits EMT Progression by Regulating Notch1 Pathway in NSCLC |
External Links
| Links for NBR2 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |