Basic Information
| LncRNA/CircRNA Name | NBR2 |
| Synonyms | neighbor of BRCA1 lncRNA 2 |
| Region | GRCh38_17:43125610-43153671 |
| Ensemble | ENSG00000198496 |
| Refseq | NR_003108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Curcumin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Western blotting, RT-PCR |
| Sample | 4 human CRC cell lines, including HCT116, HCT8, SW480, and SW620 |
| Expression Pattern | up-regulated |
| Function Description | Current data showed that glucose deficiency increased the expression of NBR2 in colorectal cancer cells, and NBR2 knockdown affected the progression of colorectal cancer cells under glucose starvation conditions. When NBR2 was silenced in the treated colorectal cancer cells, the proliferation, the clone formation, and the percentage of S-phase cells suppressed by glucose deprivation were compromised. Furthermore, NBR2 knockdown could suppress glucose deprivation-induced adenosine monophosphate-activated protein kinase activation plus mTOR inactivation. Similarly, when colorectal cancer cells were treated with curcumin, the expression of NBR2 was significantly increased.NBR2 knockdown abolished curcumin-induced activation of adenosine monophosphate-activated protein kinase and inactivation of the mTOR signaling pathway. |
| Pubmed ID | 31888414 |
| Year | 2019 |
| Title | Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway |
External Links
| Links for NBR2 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |