Basic Information
LncRNA/CircRNA Name | NBAT1 |
Synonyms | NBAT1, CASC14, NBAT-1 |
Region | GRCh38_6:22134957-22147193 |
Ensemble | ENSG00000260455 |
Refseq | NR_034143 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | lung cancer |
ICD-0-3 | C34 |
Methods | qPCR, Western blot etc. |
Sample | cell line (A549), NSCLC tissues |
Expression Pattern | down-regulated |
Function Description | The expression level of lncRNA NBAT-1 in cancer specimen was remarkably lower than that in adjacent areas. Furthermore, the low expression of lncRNA NBAT-1 had a significant correlation with patient's tumor size, differentiation degree of tumor cells and lymph node metastasis. The overexpression of lncRNA NBAT-1 could inhibit the proliferation and cell cycle, promote the apoptosis of A549 cells, and down-regulate the expression level of RAC1.The low expression of lncRNA NBAT-1 is involved in the progression of lung cancer. |
Pubmed ID | 29687849 |
Year | 2018 |
Title | LncRNA NBAT-1 is down-regulated in lung cancer and influences cell proliferation, apoptosis and cell cycle. |
External Links
Links for NBAT1 | GenBank HGNC NONCODE |
Links for lung cancer | OMIM COSMIC |