Basic Information
| LncRNA/CircRNA Name | n339260 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot |
| Sample | hepatocellular carcinoma tissues, cell lines (HepG2, 293T) |
| Expression Pattern | up-regulated |
| Function Description | we demonstrated that expression of the lncRNA, n339260, is associated with CSC phenotype in HCC, and n339260 level correlated with VM, metastasis, and shorter survival time in an animal model. Overexpression of n339260 in HepG2 cells was associated with a significant increase in CSC. Twenty-eight miRNAs were found to be differentially expressed following n339260 downregulation in HCS cells, which included 18 upregulated miRNAs and 10 downregulated miRNAs. |
| Pubmed ID | 30022558 |
| Year | 2018 |
| Title | Long Noncoding RNA n339260 Promotes Vasculogenic Mimicry and Cancer Stem Cell Development in Hepatocellular Carcinoma. |
External Links
| Links for n339260 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |