Basic Information
| LncRNA/CircRNA Name | n335586 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot etc. |
| Sample | hepatocellular carcinoma tissues, cell lines (Huh7 and HepG2) |
| Expression Pattern | up-regulated |
| Function Description | the expression of n335586 was significantly increased in HBV positive HCC tissues and cells and was induced by HBV in vitro.Function study indicated that lncRNA n335586 remarkably promoted HCC cells migration, invasion and epithelial-mesenchymal transition (EMT) in vitro and metastasis in vivo.Further mechanistic studies showed lncRNA n335586 promoted HCC cells migration and invasion through facilitating the expression of its host gene CKMT1A by competitively binding miR-924. In conclusion,we demonstrated that the n335586/miR-924/CKMT1A axis contributes to HCC cell migration and invasion, which may be helpful for understanding of pathogenesis of HBV-related HCC. Because lncRNA n335586 overlapped with part of CDS and 3??UTR of CKMT1A,we speculated that it may operate in ceRNA manner. |
| Pubmed ID | 29753758 |
| Year | 2018 |
| Title | LncRNA n335586/miR-924/CKMT1A axis contributes to cell migration and invasion in hepatocellular carcinoma cells. |
External Links
| Links for n335586 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |