Basic Information
| LncRNA/CircRNA Name | MYU |
| Synonyms | VPS9D1-AS1, MYU |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, RIP, RNA pull-down assay etc. |
| Sample | cell lines (LS180 and DLD-1) |
| Expression Pattern | up-regulated |
| Function Description | Here, we identify a direct target of c-Myc, termed MYU, and show that MYU is upregulated in most colon cancers and required for the tumorigenicity of colon cancer cells. Furthermore, we demonstrate that MYU associates with the RNA binding protein hnRNP-K to stabilize CDK6 expression and thereby promotes the G1-S transition of the cell cycle. |
| Pubmed ID | 27568568 |
| Year | 2016 |
| Title | MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression. |
External Links
| Links for MYU | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |