Basic Information
| LncRNA/CircRNA Name | MYCNOS |
| Synonyms | MYCNOS, MYCN-AS1, N-CYM, NCYM, NYCM |
| Region | GRCh38_2:15921037-15942249 |
| Ensemble | ENSG00000233718 |
| Refseq | NM_001329968 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | neuroblastoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Both DeltaMYCN and MYCNOS are expressed in all NBs examined. In NBs with MYCN-amplification, these transcripts are significantly higher expressed. Expression of the antisense gene MYCNOS might be relevant to the progression of NB, potentially by directly inhibiting MYCN transcription by transcriptional interference at the DNA level. The MYCNOS:MYCN-ratio in NBs is significantly correlated with both MYCN-amplification and NB-stage. Our data indicate that in NB, MYCN expression levels might be influenced by MYCNOS but not by ??YCN. |
| Pubmed ID | 19615087 |
| Year | 2009 |
| Title | Regulation of MYCN expression in human neuroblastoma cells. |
External Links
| Links for MYCNOS | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |