Basic Information
| LncRNA/CircRNA Name | MYCNOS |
| Synonyms | NA |
| Region | GRCh38_2:15921037-15942249 |
| Ensemble | ENSG00000233718 |
| Refseq | NM_001329968 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc |
| Sample | HCC tissues,cell lines (HL-7702, Huh-7, Hep3B, JHH-7, and SNU398 ) |
| Expression Pattern | up-regulated |
| Function Description | MYCNOS was up-regulated in both HCC tissues and cell lines, and elevated MYCNOS expression was correlated to shorter survival time of HCC patients. We knocked down MYCNOS expression using short hairpin RNAs specifically targeting MYCNOS. MYCNOS knockdown significantly inhibited proliferation in HCC cells in vitro accompanied by exacerbated cell apoptosis; it also suppressed tumor growth in mouse model in vivo. |
| Pubmed ID | 31776854 |
| Year | 2019 |
| Title | LncRNA MYCNOS Facilitates Proliferation and Invasion in Hepatocellular Carcinoma by Regulating miR-340 |
External Links
| Links for MYCNOS | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |