Basic Information
| LncRNA/CircRNA Name | MYCLo-6 |
| Synonyms | LPP-AS2, MYCLo-5, MYCLo-6 |
| Region | GRCh38_3:188151206-188154057 |
| Ensemble | ENSG00000270959 |
| Refseq | NR_036497 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | cell lines (HCT116, RKO, HT29, A549, PC3, MCF7 and SKBR3, SK-HEP-1 and HepG2) |
| Expression Pattern | down-regulated |
| Function Description | Of the tested cell lines, MYCLo-4 was upregulated by MYC knockdown in HCT116 (CRC), RKO (CRC), HT29 (colorectal adenocarcinoma), A549 (Lung carcinoma) and PC3 (prostate cancer). The other 2 lncRNAs, MYCLo-5 and -6 were also induced by MYC repression in various cancer types such as CRC (HCT116, RKO and HT29), lung cancer (A549), prostate cancer (PC3), breast cancer (MCF7 and SKBR3) and hepatocellular carcinoma (SK-HEP-1 and HepG2). |
| Pubmed ID | 26003165 |
| Year | 2015 |
| Title | MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression. |
External Links
| Links for MYCLo-6 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |