Basic Information
| LncRNA/CircRNA Name | MVIH |
| Synonyms | AK094613 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Flow cytometry assay etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MCF-7, T47D, BT-549, UACC-812) |
| Expression Pattern | up-regulated |
| Function Description | Our research revealed that the expression levels of MVIH in breast cancer tissues were higher than in adjacent noncancerous tissues, and high MVIH expression was correlated with Ki67 expression. Moreover, breast cancer patients with high MVIH expression levels showed poor overall survival and disease-free survival. Multivariate analysis results indicated that MVIH was an independent prognostic factor in breast cancer. In addition, upregulated MVIH expression levels promoted cell proliferation and cell cycle, and inhibited cell apoptosis, while reduced MVIH expression showed the converse. |
| Pubmed ID | 26555546 |
| Year | 2015 |
| Title | Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer. |
External Links
| Links for MVIH | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |