Basic Information
| LncRNA/CircRNA Name | MTM |
| Synonyms | MT1JP, MT1, MT1J, MT1NP, MTB |
| Region | GRCh38_16:56643705-56644786 |
| Ensemble | ENSG00000205361 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | gastric mucosa tissues, cell lines (AGS, BGC823, HGC27, MGC803, SGC7901, MKN28, MKN45) |
| Expression Pattern | down-regulated |
| Function Description | MTM expression was significantly lower in GC cell lines and tissues, and closely correlated with lymphatic metastasis, invasive depth, tumor staging and overall survival. Overexpression of MTM significantly inhibited GC cell migration and invasion, suppressed cell proliferation and induced cell apoptosis. In addition, we found a positive correlation between the expression level of MTM and MT1F both in cell and tissue samples. MT1F overexpression decreased GC cell migration and invasion, while knockdown of MT1F restored cell migration and invasion in MTM-overexpressing GC cells, suggesting MT1F as a key target of MTM. |
| Pubmed ID | 29228617 |
| Year | 2017 |
| Title | Decreased long non-coding RNA MTM contributes to gastric cancer cell migration and invasion via modulating MT1F |
External Links
| Links for MTM | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |