Basic Information
| LncRNA/CircRNA Name | MTA2TR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, RNAi, other |
| Sample | PC tissues and cell lines (PANC-1, BxPC-3 and SW1990) |
| Expression Pattern | up-regulated |
| Function Description | Furthermore, we found that depletion of MTA2TR significantly inhibited PC cell proliferation and invasion both in vitro and in vivo. We further demonstrated that MTA2TR transcriptionally upregulates MTA2 expression by recruiting activating transcription factor 3 (ATF3) to the promoter area of MTA2. Consequentially, MTA2 can stabilize the HIF-1? protein via deacetylation, which further activates HIF-1? transcriptional activity. Interestingly, our results revealed that MTA2TR is transcriptionally regulated by HIF-1? under hypoxic conditions. Our clinical samples further indicated that the overexpression of MTA2TR was correlated with MTA2 upregulation, as well as with reduced overall survival (OS) in PC patients. |
| Pubmed ID | 31410216 |
| Year | 2019 |
| Title | Deregulated lncRNA Expression Profile in the Mouse Lung Adenocarcinomas With KRAS-G12D Mutation and P53 Knockout |
External Links
| Links for MTA2TR | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |