Basic Information
| LncRNA/CircRNA Name | MT1JP |
| Synonyms | MT1JP, MT1, MT1J, MT1NP, MTB |
| Region | GRCh38_16:56635739-56637086 |
| Ensemble | ENSG00000255986 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | LncRNA MT1JP was significantly lower in GC tissues than adjacent normal tissues,and higher MT1JP was remarkably related to lymph node metastasis and advance stage. Functional analysis showed that lncRNA MT1JP regulated FBXW7 expression by competitively binding to miR-92a-3p. MiR-92a-3p and down-regulated FBXW7 reversed cell phenotypes caused by lncRNA MT1JP by rescue analysis.MT1JP, a down-regulated lncRNA in GC,was associated with malignant tumor phenotypes and survival of GC.MT1JP regulated the progression of GC by functioning as a competing endogenous RNA (ceRNA) to competitively bind to miR-92a-3p and regulate FBXW7 expression. Our study provided new insight into the post-transcriptional regulation mechanism of lncRNA MT1JP,and suggested that MT1JP may act as a potential therapeutic target and prognosis biomarker for GC. |
| Pubmed ID | 29720189 |
| Year | 2018 |
| Title | LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer. |
External Links
| Links for MT1JP | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |