Basic Information
| LncRNA/CircRNA Name | MT1JP |
| Synonyms | MT1JP, MT1, MT1J, MT1NP, MTB |
| Region | GRCh38_16:56635739-56637086 |
| Ensemble | ENSG00000255986 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, Northern blot etc. |
| Sample | cell lines (L02, SMMC-7721 and HepG2) |
| Expression Pattern | down-regulated |
| Function Description | The results of qRT-PCR analyses showed that MT1JP is expressed at higher levels in non-cancerous than in cancerous cell lines, consistent with the results from the tissue samples. By associating with the RNA-binding protein TIAR, MT1JP enhanced the translation of the master transcription factor p53, thereby regulating a series of pathways involving p53, such as the cell cycle, apoptosis and proliferation. When MT1JP was down-regulated, the protein level of p53 declined, which in turn accelerated cell deterioration and tumor formation. Moreover, differential expression of MT1JP in cancerous and normal tissues suggests that it may be a promising prognostic marker and a therapeutic target. |
| Pubmed ID | 26909858 |
| Year | 2016 |
| Title | LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway. |
External Links
| Links for MT1JP | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |