Basic Information
| LncRNA/CircRNA Name | MT1JP |
| Synonyms | MT1JP, MT1, MT1J, MT1NP, MTB |
| Region | GRCh38_16:56635739-56637086 |
| Ensemble | ENSG00000255986 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qPCR, Western blot |
| Sample | retinoblastoma tissues, cell lines (Weri-Rb1, Y79) |
| Expression Pattern | down-regulated |
| Function Description | The results revealed that MT1JP was down-regulated, while ?-catenin was highly expressed in retinoblastoma cells. Low Expression of MT1JP is Related to Poor Prognosis in Patients With RB. Additionally, the expression of MT1JP was found to be associated with IIRC stage, optic nerve invasion, and nodal or distant metastasis. Up-Regulated MT1JP Suppresses the Proliferation of RB Cells Via Inducing Cell Cycle and Apoptosis Variations. Up-Regulated MT1JP Represses Cell Migration and Invasion Via Triggering EMT Alteration. |
| Pubmed ID | 30024609 |
| Year | 2018 |
| Title | LncRNA MT1JP Acts as a Tumor Inhibitor via Reciprocally Regulating Wnt/?-Catenin Pathway in Retinoblastoma. |
External Links
| Links for MT1JP | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |