Basic Information
| LncRNA/CircRNA Name | MT1JP |
| Synonyms | MT1JP, MT1, MT1J, MT1NP, MTB |
| Region | GRCh38_16:56635739-56637086 |
| Ensemble | ENSG00000255986 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot etc. |
| Sample | glioma and normal brain tissues human glioma cell lines(U87, U251, and SNB19) |
| Expression Pattern | down-regulated |
| Function Description | MT1JP expression was downregulated in glioma tissues and cells. The low expression of MT1JP was considered as an independent risk factor for predicting overall survival in gliomas.After transfection of MT1JP overexpression plasmid, glioma cells showed decreased proliferation, migration and invasion ability, increased apoptosis rate, and decreased the tumorigenic ability of nude mice. The trends were opposite in glioma cells transfected with MT1JP poor expression plasmid. |
| Pubmed ID | 31066040 |
| Year | 2019 |
| Title | Long Noncoding RNA MT1JP Inhibits Proliferation, Invasion, and Migration While Promoting Apoptosis of Glioma Cells Through the Activation of PTEN/Akt Signaling Pathway.After transfection of MT1JP overexpression plasmid, glioma cells showed decreased proliferation, migration and invasion ability, increased apoptosis rate, and decreased the tumorigenic ability of nude mice. |
External Links
| Links for MT1JP | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |