Basic Information
| LncRNA/CircRNA Name | MT1DP |
| Synonyms | MT1JP, MT1, MT1J, MT1NP, MTB |
| Region | GRCh38_16:56643705-56644786 |
| Ensemble | ENSG00000205361 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (SMMC-7721, Bel-7402, Huh7, HepG2, DLD-1, LS174T) |
| Expression Pattern | down-regulated |
| Function Description | Overexpression of MT1DP resulted in reduced cell proliferation and colony formation in soft agar, but increased apoptosis in liver cancer cells, whereas knockdown of this lncRNA had the opposite effetc, indicating that MT1DP acts as a tumor suppressor. Furthermore, MT1DP was revealed as a negative regulator of Alfa-fetoprotein (AFP), a classic liver cancer tumor marker, through inhibiting protein synthesis of Forkhead box A1 (FoxA1), an important transcription factor in liver development and cancer progression. |
| Pubmed ID | 25261601 |
| Year | 2014 |
| Title | Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells. |
External Links
| Links for MT1DP | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |