Basic Information
| LncRNA/CircRNA Name | MRPL39 |
| Synonyms | C21orf92, L39mt, L5mt, MRP-L5, MRPL5, MSTP003, PRED22, PRED66, RPML5 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Luciferase reporter assay, other |
| Sample | GC tissues and cell lines (BGC823, AGS, and SGC-7901) |
| Expression Pattern | down-regulated |
| Function Description | Over-expression of MRPL39 in the GC cell lines BGC823 and SGC-7901 inhibited cell growth, proliferation, migration, and invasion. MiR-130, a putative target gene of MRPL39, displayed an inverse association with the expression of MRPL39 in GC tissues and cell lines. Moreover, a luciferase assay demonstrated a direct binding between the miR-130 and MRPL39, and the reintroduction of miR-130 abrogated the anti-tumor effect of MRPL39 on GC cells. |
| Pubmed ID | 30452299 |
| Year | 2018 |
| Title | Long Noncoding RNA MRPL39 Inhibits Gastric Cancer Proliferation and Progression by Directly Targeting miR-130 |
External Links
| Links for MRPL39 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |