Basic Information
| LncRNA/CircRNA Name | MPPED2-AS1 |
| Synonyms | NA |
| Region | GRCh38_11:30584130-30630508 |
| Ensemble | ENSG00000254489 |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Western blot , RIP , Microarray etc. |
| Sample | Normal and neoplastic human breast tissues ,Human breast cancer cell lines( MDA-MB-231, SKBR3, MDA-MB-468 and MCF7) |
| Expression Pattern | down-regulated |
| Function Description | MPPED2 expression was decreased in breast cancer samples.Interestingly, the hypermethylation of MPPED2 promoter likely accounted for its downregulation in breast cancer. MPPED2-AS1 was found downregulated in breast cancer tissues and, intriguingly, its expression decreased the hypermethylation of the MPPED2 promoter by inhibiting DNA methyltransferase 1 (DNMT1). Furthermore, the restoration of MPPED2 expression reduced cell proliferation, migration and invasion capability of breast carcinoma cell lines. |
| Pubmed ID | 31181813 |
| Year | 2019 |
| Title | The?Metallophosphoesterase-Domain-Containing Protein 2?(?MPPED2) Gene Acts as Tumor Suppressor in Breast Cancer |
External Links
| Links for MPPED2-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |