Basic Information
| LncRNA/CircRNA Name | MNX1-AS1 |
| Synonyms | MNX1-AS1, CCAT5 |
| Region | GRCh38_7:157010805-157016426 |
| Ensemble | ENSG00000243479 |
| Refseq | NR_038835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | glioblastoma tissues, cell lines (U138, LN229, T98 and U251) |
| Expression Pattern | up-regulated |
| Function Description | the expression of MNX1-AS1 was significantly upregulated in GBM tissues and cell lines.Knockdown of MNX1-AS1 significantly inhibited the proliferation,migration and invasion of GBM cells. In terms of mechanism,we found that MNX1-AS1 could bind to miR-4443 in GBM cells.Overexpression of miR-4443 significantly inhibited the expression of MNX1-AS1, and vice versa. Moreover,there was an inverse correlation between the expression levels of MNX1-AS1 and miR-4443 in GBM tissues. Moreover,we found that overexpression of miR-4443 inhibited the proliferation, migration and invasion of GBM cells. Besides,we showed that inhibition of miR-4443 reversed the effects of MNX1-AS1 knockdown on GBM cell proliferation, migration and invasion. |
| Pubmed ID | 29678219 |
| Year | 2018 |
| Title | LncRNA MNX1-AS1 promotes glioblastoma progression through inhibition of miR-4443. |
External Links
| Links for MNX1-AS1 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |