Basic Information
| LncRNA/CircRNA Name | MNX1-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:157010805-157016426 |
| Ensemble | ENSG00000243479 |
| Refseq | NR_038835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | Human ESCC cell lines (TE-13, TE-1, EC-1, and Eca-109) and normal human esophageal epithelial-1 cell line (HEEC), ESCC tissues., adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | The expression level of MNX1-AS1 was significantly increased in both ESCC tissues sample and cells. Moreover, knockdown of MNX1-AS1 markedly inhibited the migration and invasion of ESCC cells. Besides, knockdown of MNX1-AS1 remarkably down-regulated the mRNA and protein levels of insulin-like growth factor 2 (IGF2). Furthermore, IGF2 expression was positively correlated with MNX1-AS1 expression in ESCC tissues. |
| Pubmed ID | 31364117 |
| Year | 2019 |
| Title | Long non-coding RNA MNX1-AS1 promotes migration and invasion of esophageal squamous cell carcinoma by upregulating IGF2 |
External Links
| Links for MNX1-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |